Endocrine Abstracts

Introduction: LH and hCG act on the same receptor (LHCGR), have different half-lives and in vivo biopotency. It is not known whether they elicit the same cellular and molecular response. The aim of this study was to compare the kinetics of cAMP response to recombinant LH and hCG.Design: In COS-7 cells permanently expressing the human LHCGR (COS-7/LHCGR) we evaluated LH and hCG dose-response curves, by measuring total cAMP after 3 h of incubation. ...

Introduction: Metachronic metastasis of renal carcinoma to the thyroid gland, a rare entity occurring sometimes many years after nephrectomy, have been already reported by literature. Thyroidal synchronous metastasis, instead, are more uncommon. We herein report a patient with thyroidal metastasis and intrajugular thrombo embolic involvement as initial presentation of a misunderstood renal carcinoma.Case Report: A 83-years-old woman, with silent medical ...

We present a 27 year-old female patient suffering from multiple sclerosis (MS) since 3 years ago. She currently consults for menstrual disturbances. She has not any neurological secuelae of MS now and she is not on medical treatment. She is with amenorrhea since 10 months ago, but she had been oligomenorrhea just before for 24 months. She doesn’t have any symptoms suspicious for other hormonal impairment. Physical examination is normal.The laborator...

Statement of the problem: Thyroid nodules are one of the most common clinical problems encountered today. Detection of these nodules have been augmented with ultrasonography and fine needle aspiration biopsy (FNAB). Worldwide, the use of international standards of reporting such as the American Thyroid Association (ATA) Sonographic Pattern Risk Assessment and the Bethesda System for Reporting Thyroid Cytopathology have been proven to detect thyroid malignancies. However, ultra...

Lipocalin-2 (LCN2) is a glycoprotein synthetized by various cell types, including neutrophils, that acts as siderophores scavenger and play an important role in different chronic inflammatory processes. Metabolic Syndrome (MetS) and Adult Growth Hormone Deficiency (AGHD), both partial and total, are characterized by inflammatory features. The objectives of our cross-sectional study were: 1) to compare LCN2 levels in these clinical pictures; 2) to evaluate the relations between...

Background: Ghrelin and its endogenous antagonist liver-expressed antimicrobial peptide-2 (LEAP-2) are involved in GH secretion, both acting on GSH-r1α, and regulation of glucose and lipids metabolism. Metabolic impairments are often accompanied by an upregulation of LEAP-2 expression, with a usual concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD), characterized by weight gain, increased fat mass and insulin resistance, represent a conditi...

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a new class of oral anti-diabetic medications that improve glycaemia by reducing the amount of glucose being absorbed in the kidneys. SGLT2 inhibitors have been proven to improve blood pressure, cardiovascular health and kidney disease. Despite their beneficial clinical effects, their exact mechanism of action is not fully explored. The aim of this project was to investigate the effect of SGLT2 ...

It is known that functional hypothalamic amenorrhea is associated with low bone turnover due to low gonadal homone levels. Estrogens are critical for activation of bone remodelling units, suppression of bone reabsorption, increase of 1-25(OH)Vitamin D receptors expression. Other mechanisms could be operative, including improper diet and unbalanced exercise; however the physiopathology of such a condition is not entirely known. In order to evaluate the correlation between pitui...

Aim: To assess survival rate and prognosis factors in a group of 65 patients with distant metastases from differentiated thyroid carcinoma.Methods: Patients with metastatic differentiated thyroid carcinoma (MDTC) were retrospectively identified from the database of a single institution (1975–2008). Disease-specific survival (DSS) was analyzed by the Kaplan-Meier method.Results: A total of 65 patients with MDTC were identified....

Aim: To analyze clinical features in a group of 65 patients with differentiated thyroid carcinoma and distant metastases.Methods: Retrospective review of 65 patients with Metastatic Differentiated Thyroid Carcinoma (MDTC) identified from the database of a tertiary hospital between 1975 and 2008.Results: Sixty five patients were identified (21 males, 44 females) with a mean age of 58,9 years. The median follow-up after discovery of ...